Mutagenesis Induced by Radiation

Ionizing radiation-induced mutagenesis in Isaria fumosorosea

Mutagenesis and Background Neutron Radiation

In microelectronics, single failure events sporadically occur which, in some areas, like plane and space navigation, could have catastrophic consequences. Preliminary estimations [1] and more recent experiments [2] indicate a correlation between these events and the Background Neutron Radiation (BNR) [3]. The mechanism of failure is the collision of a neutron from the BNR with an atomic nucleus...

Mutagenesis by metal-induced oxygen radicals.

To assess the contribution of reactive oxygen species (ROS) to metal-induced mutagenesis, we have determined the spectrum of mutations in the lacZ alpha gene after exposure of M13mp2 DNA to Fe2+, Cu2+, and Ni2+. With iron and copper ions, mutations are clustered and are predominantly single-base substitutions. Fe, Cu, and phorbol ester-stimulated neutrophils also produced tandem double CC-->TT ...

In vivo Analysis of H2AX Phosphorylation Induced by γ-Radiation

ABSTRACT          Background and Objectives: Exposure to ionizing radiation in modern societies is inevitable and can cause a variety of adverse health effects such as cancer and birth defects. Therefore, a reliable, repeatable and sensitive method is required for evaluation of radiation exposure. The aim of this study was to determine the amount of hist...

RBE-LET relationships in mutagenesis by ionizing radiation.

The paper considers the relationship between the quality of radiation and biological lesions produced by ionizing radiation. The paper provides a brief review of the modelling of induction of strand breakage, chromosome aberration, revertant mutation in bacteria and Drosophila melanogaster. Experimental data are presented for the relative biological effectiveness of helium ions and alpha-partic...